Cutting edge research shows why caloric restriction increases lifespan.

The following is a series of reference studies that are showing exciting new understanding of the vitamin B3 and how it can reverse the aging process at a genetic level.

https://www.sciencedaily.com/releases/2017/03/170323141340.htm#.WQk93n2Ae1s.facebook

“Treating mice with a NAD+ precursor, or “booster,” called NMN improved their cells’ ability to repair DNA damage caused by radiation exposure or old age.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616313/

” Consequently, our results indicate that the natural vitamin, NR, could be used as a nutritional supplement to ameliorate metabolic and age-related disorders characterized by defective mitochondrial function.”

https://now.uiowa.edu/2016/10/vitamin-b3-metabolite

“The human trial involved six men and six women, all healthy. Each participant received separate oral doses of 100, 300, or 1,000 mg of NR, with a seven-day gap between doses. After each dose, Brenner’s team collected and analyzed blood and urine samples from the participants, then measured various NAD+ metabolites in the samples using a process called metabolomics. The trial showed that the NR vitamin increased NAD+ metabolism by amounts directly related to the dose, and there were no serious side effects with any of the doses.”

“Studies in mice have shown that boosting the levels of this cell metabolite—nicotinamide adenine dinucleotide, known as NAD+—can produce multiple health benefits, including resistance to weight gain, improved control of blood sugar and cholesterol, reduced nerve damage, and longer lifespan. Levels of NAD+ diminish with age, and other studies have suggested that loss of this metabolite may play a role in age-related health decline.”

“In particular, the researchers compared the ability of all three NAD+ precursor vitamins—NR, niacin, and nicotinamide—to boost NAD+ metabolism and stimulate the activity of certain enzymes that have been linked to longevity and health benefits. The study showed for the first time that oral NR is superior to nicotinamide, which is better than niacin in terms of the total amount of NAD+ produced at an equivalent dose. NR was also the best of the three in stimulating the activity of sirtuin enzymes. However, in this case, NR was the best at stimulating sirtuin-like activities, followed by niacin, followed by nicotinamide.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101544/

“In mammals, there are seven sirtuins, named SIRT1 to SIRT7. They are involved in a much broader range of cellular processes and pathways with distinct cellular localization and molecular targets”

“Calorie restriction (CR) is the most robust way to extend lifespan in most model organisms studied so far, from yeast to primates. Yet, its molecular mechanism remains elusive 43. After the discovery of sirtuins as a class of conserved aging regulators, genetic studies in simple organisms, such as yeast and fruit fly, suggested sirtuins mediates the effects of CR”

Despite controversies, can sirtuins be therapeutic targets in future medicine?

The answer is most likely affirmative for most researchers studying sirtuins and their functions. This is because, despite so many controversies, mammalian sirtuins have been clearly shown as a class of critical factors regulating many cellular processes, playing important functions in diverse tissues and systems. Sirtuin functions have been described in the central/peripheral nerve system, cardiovascular system, immune system, liver, bone, skeletal muscles, stem cells, and tissue regeneration. They have also been associated with most major diseases, such as cardiovascular diseases, cancer, metabolic disorders, neurodegenerative diseases, arthritis, and osteoporosis, all of which are age-related. For instance, in several types of cancers, knocking down SIRT1 sensitizes cancer cells to radiation and chemotherapies.”

Omega 3 Fish Oil Reduce Heart Disease Mortality after a Heart Attack

file:///C:/Users/Dr%20Drumright/Downloads/CIR.0000000000000482.full.pdf

ABSTRACT: Multiple randomized controlled trials (RCTs) have assessed the effects of supplementation with eicosapentaenoic acid plus docosahexaenoic acid (omega-3 polyunsaturated fatty acids, commonly called fish oils) on the occurrence of clinical cardiovascular diseases. Although the effects of supplementation for the primary prevention of clinical cardiovascular events in the general population have not been examined, RCTs have assessed the role of supplementation in secondary prevention among patients with diabetes mellitus and prediabetes, patients at high risk of cardiovascular disease, and those with prevalent coronary heart disease. In this scientific advisory, we take a clinical approach and focus on common indications for omega-3 polyunsaturated fatty acid supplements related to the prevention of clinical cardiovascular events. We limited the scope of our review to large RCTs of supplementation with major clinical cardiovascular disease end points; meta-analyses were considered secondarily. We discuss the features of available RCTs and provide the rationale for our recommendations. We then use existing American Heart Association criteria to assess the strength of the recommendation and the level of evidence. On the basis of our review of the cumulative evidence from RCTs designed to assess the effect of omega-3 polyunsaturated fatty acid supplementation on clinical cardiovascular events, we update prior recommendations for patients with prevalent coronary heart disease, and we offer recommendations, when data are available, for patients with other clinical indications, including patients with diabetes mellitus and prediabetes and those with high risk of cardiovascular disease, stroke, heart failure, and atrial fibrillation

The Three Treasures

A part of the Dao Te Ching, Lao Tzu speaks on the topic of the three treasures.

I have found this particular lesson is most useful for people of at least 40 years of life experience.

The first treasure is Love.  Spend you time doing the things you love to do.  If you find yourself spending time doing something you don’t love, then either learn to love it or do something else.

The second treasure is Moderation.  Do what you love doing in moderation.  Too much of anything causes imbalances in your body and mind and leads to catastrophes.

The third treasure is Humility.  This one doesn’t quite translate well.  He doesn’t speak of the type of humility like bowing before a greater power.  This humility is a reminder that as you become successful in life there will be riches, rewards, admiration, and other things happen.  Being humble is keeping focused on doing what you love and not getting lost in the trappings of success.

Remind yourself of these simply truths each day and the reward will be many years of continued happiness and success for you and everyone you can help.

welcome back

It has been a long while since i used this page to communicate.  Facebook has taken most of my time.  In 2017 I want to create something a little more lasting than Facebook and will start blogging here again.  See you soon.

Vaccine myth 2016

Corrupt to the core.

Senator Posey Calls for Investigation of CDC Fraud Senator Posey discusses how Dr. Bill Thompson and his colleagues hid data connecting autism and the MMR vaccine. Then they agreed to destroy all documents related to the study. Correctly believing this was an illegal act, Dr. Thompson kept copies of all documents and data files.”